Figure 2. Intra-VTA, but not intra-SNr, infusions reduce ethanol self-administration, but have no effect on sucrose self-administration.
A. Infusions of almorexant into the VTA significantly reduced active lever responding for 20% ethanol but (B.) had no effect on 5% sucrose responding. C. Schematic representation of the VTA cannula placements. D. Infusions of almorexant into the SNr had no effect on active lever responding for 20% ethanol. E. Schematic representation of the SNr cannula placements. Values are expressed as mean active lever presses ± SEM (repeated measures ANOVA followed by Newman Keuls post hoc testing,* p<0.05 compared to vehicle for VTA groups and paired t-test for SNr data), n = 12 for VTA ethanol, n = 8 for VTA sucrose and n = 9 for the SNr ethanol.