Table 3. Ratio metafeatures clustered with MMSE score.
Metafeature (Gene Symbol. Probe Set ID) | Correlation Coefficient | Common KEGG Pathways |
PPIA.212661_x_at/C3orf60.209177_at | 0.884365 | |
PIGO.209998_at/CASK.211208_s_at | 0.760958 | |
PURA.213806_at/AJ225093.211835_at | 0.673877 | |
PRKCB1.209685_s_at/PTEN.222176_at | −0.68675 | Phosphatidylinositol signaling system |
FOXO1.202724_s_at/ACACA.212186_at | −0.78654 | Insulin signaling pathway |
CASK.211208_s_at/PTEN.222176_at | −0.83565 | Tight junction |
RPL23A.203012_x_at/ATP5C1.213366_x_at | −0.83758 | |
CASK.211208_s_at/ATP5C1.213366_x_at | −0.86355 | |
ACACA.212186_at/LDHA.200650_s_at | −0.87642 | Propanoate metabolism |
PRKAR2B.203680_at/ACACA.212186_at | −0.88001 | Insulin signaling pathway |
COX6A1.200925_at/ATP5C1.213366_x_at | −0.88233 | Oxidative phosphorylation |
RPL23A.203012_x_at/PPIA.211765_x_at | −0.88328 | |
ACTN1.208636_at/VCL.200930_s_at | −0.88344 | Focal adhesion |
ITGB8.205816_at/TTN.208195_at | −0.88642 | Focal adhesion |
ITGB8.205816_at/PTN.209466_x_at | −0.88642 | Focal adhesion |
CPT2.204264_at/ATP5C1.213366_x_at | −0.89851 | |
TTN.208195_at/PRKCB1.209685_s_at | −0.90065 | Focal adhesion |
SDC1.201287_s_at/DDX1.201241_at | −0.90504 | |
TTN.208195_at/NEFL.221805_at | −0.91592 | |
ZNF34.219801_at/FXYD6.217897_at | −0.9181 | |
AL359052.214927_at/ATP5C1.205711_x_at | −0.9188 | |
NUCKS1.217802_s_at/PPIA.212661_x_at | −0.91944 | |
TCF7L2.212761_at/ACTN1.208636_at | −0.92353 | Adherens junction |
TTN.208195_at/VSNL1.203798_s_at | −0.93006 | |
CASK.211208_s_at/PTN.209466_x_at | −0.9301 | |
NM_024849.220531_at/MRPL16.217980_s_at | −0.93682 | |
AJ225093.211835_at/ATP5C1.205711_x_at | −0.93986 | |
C10orf76.55662_at/PPIA.212661_x_at | −0.94211 | |
ITGB8.205816_at/SDC1.201287_s_at | −0.95719 | ECM-receptor interaction |
ITGB8.205816_at/PPIA.212661_x_at | −0.95911 | |
CASK.211208_s_at/PPIA.211765_x_at | −0.95641 | |
TUG1.222244_s_at/SCFD1.215548_s_at | −0.95643 |
Metafeatures are ordered by Spearman’s rank correlation with MMSE score. Genes in boldface indicate that they were previously discussed in [5] and genes with underlined boldface represent the cases for which the gene has been discussed in the context of AD in the published literature.