Table 8. Ratio-sum-difference-product metafeatures clustered with MMSE score.
| Metafeature (Gene Symbol. Probe Set ID) | Correlation Coefficient | Common KEGG Pathways |
| ICA1.207949_s_at-ITGB8.205816_at | 0.940945 | |
| GABBR2.209990_s_at+PPIA.212661_x_at | 0.9268 | |
| LTBP1.202728_s_at-ITGB8.205816_at | 0.923973 | |
| RRAD.204803_s_at-ITGB8.205816_at | 0.922066 | |
| CSPG5.39966_at*ATP5C1.213366_x_at | 0.917444 | |
| ATP5C1.213366_x_at*FXYD6.217897_at | 0.911438 | |
| MKL2.218259_at+PPIA.212661_x_at | 0.909957 | |
| PPIA.212661_x_at+ATP2B2.204685_s_at | 0.908852 | |
| ATP5C1.213366_x_at+KIAA1107.214098_at | 0.903328 | |
| ICA1.207949_s_at-C10orf76.55662_at | 0.902256 | |
| PPIA.212661_x_at+KCNQ2.205737_at | 0.900168 | |
| PRKAR2B.203680_at*ACACA.212186_at | 0.8986 | Insulin signaling pathway |
| ATP5C1.205711_x_at*FXYD6.217897_at | 0.898298 | |
| VCL.200930_s_at-C10orf76.55662_at | 0.897422 | |
| PPIA.212661_x_at+ARF3.200734_s_at | 0.895376 | |
| RIBC2.206526_at-ITGB8.205816_at | 0.894556 | |
| CSPG5.39966_at+ATP5C1.213366_x_at | 0.894256 | |
| AW851559.216056_at-ZBTB20.222357_at | 0.893367 | |
| MYT1L.210016_at+PPIA.212661_x_at | 0.893136 | |
| PPIA.212661_x_at+AW514267.214945_at | 0.892278 | |
| RRAD.204803_s_at-KLHL20.204177_s_at | 0.891174 | |
| PTEN.222176_at*TTN.208195_at | 0.891049 | Focal adhesion |
| ATP5C1.213366_x_at+FXYD6.217897_at | 0.890893 | |
| AI708767.211978_x_at*FXYD6.217897_at | 0.890212 | |
| ATP5C1.213366_x_at*ACACA.212186_at | 0.888843 | |
| U82303.216702_x_at+NM_018601.220880_at | −0.90422 | |
| U82303.216702_x_at+PTEN.211711_s_at | −0.90498 | |
| ITGB8.205816_at*SDC1.201287_s_at | −0.90504 | ECM-receptor interaction |
| ZNF34.219801_at-NRG1.206343_s_at | −0.90504 | |
| U82303.216702_x_at+SERTAD2.202656_s_at | −0.90546 | |
| JPH2.220385_at+NM_024849.220531_at | −0.90598 | |
| ZBTB20.222357_at-NRG1.206343_s_at | −0.90613 | |
| U82303.216702_x_at+RBM19.205115_s_at | −0.90613 | |
| PTMS.218044_x_at+NM_024849.220531_at | −0.90683 | |
| U82303.216702_x_at+TPP1.214195_at | −0.90775 | |
| KLHL20.204177_s_at+AL359052.214927_at | −0.90825 | |
| ITGB8.205816_at+TTN.208195_at | −0.90941 | Focal adhesion |
| KLHL20.204177_s_at+UMOD.206716_at | −0.90994 | |
| TSPAN9.220968_s_at-NRG1.206343_s_at | −0.91157 | |
| C10orf76.55662_at+NM_018601.220880_at | −0.91218 | |
| C10orf76.55662_at+OTUB2.219369_s_at | −0.91235 | |
| ITGB8.205816_at+NM_014163.220695_at | −0.91264 | |
| SDC1.201287_s_at+FLJ23172.217016_x_at | −0.91266 | |
| PRKCB1.209685_s_at+ACTN1.208636_at | −0.91327 | Focal adhesion |
| BE138647.214314_s_at+AL049242.216101_at | −0.91548 | |
| TTN.208195_at/NEFL.221805_at | −0.91592 | |
| KLHL20.204177_s_at+C19orf50.200076_s_at | −0.91666 | |
| ZNF34.219801_at/FXYD6.217897_at | −0.9181 | |
| AL359052.214927_at/ATP5C1.205711_x_at | −0.9188 | |
| KLHL20.204177_s_at+SDC1.201287_s_at | −0.9188 |
We have selected 50 metafeatures (25 most positively correlated and 25 most negatively correlated) and ordered them by Spearman’s rank correlation with MMSE score. Genes in boldface indicate that they were previously discussed in [5] and genes with underlined boldface represent the cases for which the gene has been discussed in the context of AD in the published literature (see File S3 for details).