Table 9. Ratio-sum-difference-product metafeatures clustered with NFT count.
| Metafeature (Gene Symbol. Probe Set ID) | Correlation Coefficient | Common KEGG Pathways |
| CCDC121.220321_s_at+U62966.207560_at | 0.939664 | |
| CGA.204637_at+PRL.205445_at | 0.918887 | |
| AL049435.213817_at+U62966.207560_at | 0.912476 | |
| AL049242.216101_at+U62966.207560_at | 0.912476 | |
| RNF121.219021_at+GNA14.220108_at | 0.910216 | |
| U62966.207560_at+WWP1.212637_s_at | 0.90442 | |
| MED13L.212207_at+U62966.207560_at | 0.897981 | |
| F9.207218_at+U62966.207560_at | 0.897533 | |
| U62966.207560_at+C10orf76.55662_at | 0.890537 | |
| U62966.207560_at+U66059.216597_at | 0.884725 | |
| U62966.207560_at+OTUB2.219369_s_at | 0.884725 | |
| MMP11.203877_at+PRL.205445_at | 0.884093 | |
| U62966.207560_at+TEAD3.209454_s_at | 0.880455 | |
| U62966.207560_at+SPAG1.210117_at | 0.871197 | |
| TEAD1.214600_at+TOX3.216623_x_at | 0.867647 | |
| TTN.208195_at/CAST.212586_at | 0.867043 | Focal adhesion |
| TTN.208195_at*LOC100131599.213222_at | 0.866901 | |
| TTN.208195_at*AP3S1.202442_at | 0.866901 | |
| CYP3A7.211843_x_at+PRL.205445_at | 0.865975 | |
| U62966.207560_at+RNMT.202684_s_at | 0.865512 | |
| TCF7L2.212761_at*GNA14.220108_at | 0.864466 | |
| LOC286434.222196_at+U62966.207560_at | 0.86248 | |
| LOC286434.222196_at+PRL.205445_at | 0.861916 | |
| MCL1.214057_at+U62966.207560_at | 0.861243 | |
| ITGB8.205816_at+CAST.212586_at | 0.86034 | Focal adhesion |
| EDC4.202496_at+COX6B1.201441_at | −0.85128 | |
| CAST.212586_at+COX6B1.201441_at | −0.8518 | |
| TMPRSS5.221032_s_at+COX6B1.201441_at | −0.85275 | |
| SIRT3.221562_s_at+COX6B1.201441_at | −0.8535 | |
| UPF1.211168_s_at+COX6B1.201441_at | −0.85405 | |
| COX6B1.201441_at+ACCN1.206690_at | −0.85484 | |
| COX6B1.201441_at+ACTN1.211160_x_at | −0.85501 | |
| NUP98.203195_s_at+COX6B1.201441_at | −0.85527 | |
| DET1.219641_at+COX6B1.201441_at | −0.85622 | |
| ANKRD34C.216073_at+COX6B1.201441_at | −0.85845 | |
| C20orf111.209020_at+COX6B1.201441_at | −0.86017 | |
| PRKCI.213518_at-HBG2.213515_x_at | −0.86253 | |
| CYP3A7.211843_x_at+CYP26B1.219825_at | −0.86253 | Fatty acid metabolism |
| COX6B1.201441_at+DBNDD1.222234_s_at | −0.86441 | |
| UBE3B.213822_s_at+COX6B1.201441_at | −0.86685 | |
| IRF2BP1.213771_at+COX6B1.201441_at | −0.86907 | |
| COX6B1.201441_at+PCSK1.205825_at | −0.87192 | |
| IRF2BP1.213771_at+NM_005758.206809_s_at | −0.87336 | |
| B3GALT2.210121_at+COX6B1.201441_at | −0.87405 | |
| SNCG.209877_at+COX6B1.201441_at | −0.8754 | |
| COX6B1.201441_at/ATP5C1.213366_x_at | −0.87976 | Oxidative phosphorylation |
| COX6B1.201441_at+RGS4.204339_s_at | −0.88473 | |
| ALDOB.217238_s_at-PRL.205445_at | −0.89422 | |
| ICA1.207949_s_at+NPAL3.210267_at | −0.89588 | |
| COX6B1.201441_at+SORBS2.204288_s_at | −0.89721 |
We have selected 50 metafeatures (25 most positively correlated and 25 most negatively correlated) and ordered them by Spearman’s rank correlation with NFT count. Genes in boldface indicate that they were previously discussed in [5] and genes with underlined boldface represent the cases for which the gene has been discussed in the context of AD in the published literature (see File S3 for details).