Table 11. Ratio-sum-difference-product metafeatures clustered with JSDcontrol.
| Metafeature (Gene Symbol. Probe Set ID) | Correlation Coefficient | Common KEGG Pathways |
| RBM19.205115_s_at-KCNK5.219615_s_at | 0.886487 | |
| KLK3.204582_s_at-LOC645961.215320_at | 0.875436 | |
| N25732.204131_s_at-MAST3.213045_at | 0.85816 | |
| KLK3.204582_s_at-KYNU.210662_at | 0.856764 | |
| RBM19.205115_s_at-AGTR1.208016_s_at | 0.856409 | |
| ZNF669.220215_at-GEMIN6.219539_at | 0.853995 | |
| KLK3.204582_s_at-BG482805.214777_at | 0.853527 | |
| KLK3.204582_s_at/MAST3.213045_at | 0.852532 | |
| TUBD1.210389_x_at-ESR1.205225_at | 0.852098 | |
| CASP4.213596_at-LOC90379.221851_at | 0.848467 | |
| KLK3.204582_s_at-MLLT4.208512_s_at | 0.846819 | |
| GABRQ.220886_at+RBMS1.203748_x_at | 0.844336 | |
| MMP11.203876_s_at-SCGB1D2.206799_at | 0.838775 | |
| CASP4.213596_at-AF043586.216394_x_at | 0.835322 | |
| RBM19.205115_s_at-AF043586.216394_x_at | 0.834155 | |
| TMBIM1.217730_at*RBM4.200997_at | 0.833134 | |
| AL080106.216121_at-BTN2A2.205298_s_at | 0.833121 | |
| ZNF669.220215_at-TBXA2R.207554_x_at | 0.832963 | |
| ZNF669.220215_at-LOC90379.221851_at | 0.832263 | |
| SLC11A1.217507_at-SCGB1D2.206799_at | 0.83103 | |
| KLK3.204582_s_at-CSH2.208342_x_at | 0.824365 | |
| CENPE.205046_at-KYNU.210662_at | 0.823506 | |
| ZNF669.220215_at-SCGB1D2.206799_at | 0.823429 | |
| TUBD1.210389_x_at-IGSF6.206420_at | 0.819997 | |
| U62966.207560_at-NUFIP1.205136_s_at | 0.817348 | |
| MTHFD1.202309_at/MDH2.213333_at | −0.67409 | Glyoxylate and dicarboxylate metabolism |
| LDHA.200650_s_at/GOT2.200708_at | −0.72409 | Cysteine metabolism |
| IRF2BP1.213771_at-AU155105.214782_at | −0.81881 | |
| LUZP4.220665_at-ZNF669.220215_at | −0.81961 | |
| TXNDC9.203008_x_at+MAST3.213045_at | −0.82019 | |
| SMAD3.205398_s_at-MLLT4.208512_s_at | −0.82047 | Adherens junction |
| ALDOB.217238_s_at+PDE4D.211840_s_at | −0.82091 | |
| BF691447.221484_at*UBP1.218082_s_at | −0.82124 | |
| BF691447.221484_at*RNMT.202683_s_at | −0.82124 | |
| SLC9A3R2.215735_s_at-PSME3.209853_s_at | −0.82473 | |
| LOC90379.221851_at-U66059.216597_at | −0.82552 | |
| TREX1.34689_at-MARCH3.213256_at | −0.82615 | |
| AW408767.217608_at-MMP11.203876_s_at | −0.82763 | |
| PURA.213806_at-CENPE.205046_at | −0.8307 | |
| C20orf111.209020_at-PSME3.209853_s_at | −0.83454 | |
| FLJ39739.217136_at-CASP4.213596_at | −0.83709 | |
| ALDOB.217238_s_at-TNFSF14.207907_at | −0.84013 | |
| DIABLO.219350_s_at+MAST3.213045_at | −0.84039 | |
| ALDOB.217238_s_at-CASP4.213596_at | −0.84169 | |
| ICA1.207949_s_at+GCNT3.219508_at | −0.84188 | |
| S80491.216974_at-MMP11.203876_s_at | −0.84634 | |
| ALDOB.217238_s_at+SMAD3.205398_s_at | −0.8545 | |
| AKR1B1.201272_at/KLK3.204582_s_at | −0.86002 | |
| KCNJ5.208397_x_at-CASP4.213596_at | −0.86111 | |
| NDUFA10.217860_at/ATP5C1.205711_x_at | −0.86735 | Oxidative phosphorylation |
We have selected 50 metafeatures (25 most positively correlated and 25 most negatively correlated) and ordered them by Spearman’s rank correlation with JSDcontrol. Genes in boldface indicate that they were previously discussed in [5] and genes with underlined boldface represent the cases for which the gene has been discussed in the context of AD in the published literature (see File S3 for details).