Table 12. Ratio-sum-difference-product metafeatures clustered with JSDsevere.
| Metafeature (Gene Symbol. Probe Set ID) | Correlation Coefficient | Common KEGG Pathways |
| TREX1.34689_at+NM_005758.206809_s_at | 0.933423 | |
| ESR1.205225_at-AL050026.216626_at | 0.910083 | |
| VSNL1.203798_s_at-AKAP12.210517_s_at | 0.877939 | |
| PURA.213806_at-APOH.205216_s_at | 0.872983 | |
| PTEN.222176_at-AL050026.216626_at | 0.870794 | |
| MAPK1.208351_s_at+MLLT4.208512_s_at | 0.867901 | Adherens junction |
| TREX1.34689_at*COX6A1.200925_at | 0.864481 | |
| CNOT1.200861_at-GABRQ.220886_at | 0.856692 | |
| UBE3B.213822_s_at+ADK.204119_s_at | 0.847332 | |
| MTSS1.210360_s_at-PTEN.211711_s_at | 0.843329 | |
| S80491.216974_at-PTEN.211711_s_at | 0.842751 | |
| MLLT4.208512_s_at/PTEN.211711_s_at | 0.842239 | Tight junction |
| PPP2CA.208652_at/PTEN.211711_s_at | 0.842212 | Tight junction |
| P2RY10.214615_at-AL050026.216626_at | 0.842191 | |
| TTK.204822_at-PTEN.211711_s_at | 0.840396 | Inositol phosphate metabolism |
| FLJ39739.217136_at-PTEN.211711_s_at | 0.837966 | |
| UBE3B.213822_s_at+ATRN.212517_at | 0.836922 | |
| TREX1.34689_at+RPS24P2.217188_s_at | 0.83673 | |
| UBE3B.213822_s_at-FOLH1.217483_at | 0.835834 | |
| SCGB2A1.205979_at-APOH.205216_s_at | 0.83274 | |
| AJ302559.216818_s_at-KLK3.204582_s_at | 0.830253 | |
| TREX1.34689_at-PRKD2.38269_at | 0.82812 | |
| AJ302559.216818_s_at-PTEN.211711_s_at | 0.827864 | |
| TPD52.201691_s_at-FOLH1.217483_at | 0.827066 | |
| TREX1.34689_at+DDX18.208897_s_at | 0.8255 | |
| SI.206664_at+PTEN.211711_s_at | −0.80904 | |
| TNRC4.215045_at*AL536319.212606_at | −0.80962 | |
| FCAR.211307_s_at+PTEN.211711_s_at | −0.81072 | |
| AL050026.216626_at+OTUB2.219369_s_at | −0.81137 | |
| CMKLR1.210659_at+PTEN.211711_s_at | −0.81349 | |
| KLK3.204582_s_at+PTEN.211711_s_at | −0.81565 | |
| PAX3.216059_at+NM_018601.220880_at | −0.82244 | |
| AL050026.216626_at+CTAGE5.204055_s_at | −0.82288 | |
| FZD5.206136_at+PTEN.211711_s_at | −0.82362 | |
| CAMP.210244_at-SCGB1D2.206799_at | −0.82501 | |
| PTEN.211711_s_at*PIP5K1C.212518_at | −0.82503 | Phosphatidylinositol signaling system |
| PLA2G2F.215870_s_at-RARRES2.209496_at | −0.82717 | |
| BPI.205557_at+PTEN.211711_s_at | −0.8328 | |
| AI478300.217526_at-TREX1.34689_at | −0.83316 | |
| AL050026.216626_at+PTEN.211711_s_at | −0.83401 | |
| PTEN.211711_s_at-PTPRN2.203030_s_at | −0.83583 | |
| FOLH1.217483_at-SCGB1D2.206799_at | −0.83998 | |
| RAB14.200928_s_at+PTEN.211711_s_at | −0.84169 | |
| GALNT10.212256_at*SHANK2.213307_at | −0.84811 | |
| NM_004908.208254_at+PTEN.211711_s_at | −0.84856 | |
| SPRED2.212458_at*DDN.214788_x_at | −0.85116 | |
| FADS1.217462_at+PTEN.211711_s_at | −0.86774 | |
| CYP3A4.205998_x_a/CPT2.204264_at | −0.87018 | Fatty acid metabolism |
| N25732.204131_s_at/AF043586.216394_x_at | −0.9031 | |
| C3orf63.209285_s_at*DDN.214788_x_at | −0.90361 |
We have selected 50 metafeatures (25 most positively correlated and 25 most negatively correlated) and ordered them by Spearman’s rank correlation with JSDsevere. Genes in boldface indicate that they were previously discussed in [5] and genes with underlined boldface represent the cases for which the gene has been discussed in the context of AD in the published literature (see File S3 for details).