Table 1. Effect of the CD4+ T cell global DNA methylation status and the expression of different DNA methylation-related enzymes (DNMT1, DNMT3A, DNMT3B, MBD2, and MBD4) on the expression of ITGAL, PRF1, KIR2DL4, CD70, and CD40LG.

	ITGAL		PRF		KIR2DL4		CD70		CD40LG
	Controls	Patients	Controls	Patients	Controls	Patients	Controls	Patients	Controls	Patients
DNA dmC content	p = 0.028 r = 0.410	p = 0.016 r = −0.443	p = 0.308 r = 0.196	p = 0.005 r = −0.505	p = 0.610 r = 0.214	p = 0.397 r = −0.429	p = 0.754 r = 0.061	p = 0.777 r = 0.055	p = 0.172 r = 0.261	p = 0.056 r = −0.359
DNMT1	p = 0.022 r = 0.425	p = 0.237 r = 0.227	p = 0.743 r = −0.064	p = 0.140 r = 0.281	p = 0.243 r = 0.476	p = 0.497 r = 0.371	p = 0.392 r = 0.165	p = 0.709 r = 0.072	p = 0.218 r = 0.236	p = 0.095 r = 0.316
DNMT3A	p = 3×10−7 r = 0.791	p = 0.008 r = 0.483	p = 0.810 r = 0.047	p = 0.011 r = 0.467	p = 0.619 r = 0.214	p = 0.058 1 r = 0.829	p = 0.810 r = −0.047	p = 0.195 r = 0.248	p = 0.026 r = 0.412	p = 2×10−4 r = 0.636
DNMT3B	p = 2.6×10−6 r = 0.781	p = 3×10−4 r = 0.824	p = 0.094 r = 0.335	p = 0.002 r = 0.745	p = 0.215 r = 0.536	p = 0.000 2 r = 1.000	p = 0.731 r = −0.071	p = 0.175 r = 0.385	p = 0.120 r = 0.313	p = 0.034 r = 0.569
MBD2	p = 0.001 r = 0.580	p = 0.002 r = 0.549	p = 0.143 r = 0.279	p = 0.052 r = 0.365	p = 0.462 r = 0.310	p = 0.356 r = 0.486	p = 0.956 r = 0.011	p = 0.133 r = 0.286	p = 0.449 r = 0.146	p = 0.027 r = 0.411
MBD4	p = 6×10−9 r = 0.849	p = 8×10−10 r = 0.871	p = 0.115 r = 0.299	p = 0.002 r = 0.553	p = 0.151 r = 0.571	p = 0.058 1 r = 0.829	p = 0.932 r = 0.017	p = 0.187 r = −0.252	p = 0.164 r = 0.266	p = 0.120 r = 0.295

Statistically (or almost statistically) significant correlations are indicated by the p-value and the Spearman's rank correlation coefficient (r) highlighted in bold.

¹Correlation values were established for just the 6 patients from whom paired data were available.

²Correlation values were established for just the 5 patients from whom paired data were available.