Table 2. Correlation study between the CD4+ T cell global DNA methylation status and the expression of different DNA methylation-related enzymes (DNMT1, DNMT3A, DNMT3B, MBD2, and MBD4).

	DNMT3A		DNMT3B		MBD2		MBD4		DNA dm content
	Controls	Patients	Controls	Patients	Controls	Patients	Controls	Patients	Controls	Patients
DNMT1	p = 0.024 r = 0.419	p = 1×10−4 r = 0.646	p = 0.207 r = 0.256	p = 0.220 r = 0.350	p = 0.139 r = 0.281	p = 0.181 r = 0.256	p = 0.005 r = 0.503	p = 0.105 r = 0.308	p = 0.140 r = 0.281	p = 0.012 r = −0.459
DNMT3A			p = 6×10−6 r = 0.763	p = 0.106 r = 0.451	p = 0.013 r = 0.455	p = 0.009 r = 0.474	p = 7×10−10 r = 0.872	p = 0.011 r = 0.466	p = 0.108 r = 0.305	p = 0.019 r = −0.432
DNMT3B					P = 0.005 r = 0.534	p = 0.002 r = 0.741	p = 5×10−7 r = 0.811	p = 1×10−5 r = 0.901	p = 0.024 r = 0.443	p = 0.078 r = −0.486
MBD2							p = 0.001 r = 0.605	p = 0.013 r = 0.454	p = 0.019 r = 0.433	p = 0.008 r = −0.481
MBD4									p = 0.025 r = 0.417	p = 0.004 r = −0.523

Statistically (or almost statistically) significant correlations are indicated by the p-value and the Spearman's rank correlation coefficient (r) highlighted in bold.