Table 3. Artesunate + sulfadoxine-pyrimethamine vs. praziquantel in the treatment of schistosomiasis.
Citation | Year(trial) | Parasite | Location (Country) | Study Population (age) | Time point analysed (weeks) | Treatment | N°Cured/N° Treated |
Sissoko et al., 2009 [32] | 2007 | S. haematobium | Bamako (Mali) | Children (6–15) | 4 | ART+SP1 | 172/392 |
PZQ2 | 206/389 | ||||||
Mohamed et al., 2009 [51] | 2008 | S. mansoni | New Halfa (Sudan) | Children (8–17) | 4 | ART+SP3 | 27/46 |
PZQ2 | 46/46 | ||||||
Obonyo et al., 2010 [33] | 2009 | S. mansoni | Rarieda (Kenya) | Children (6–15) | 4 | ART+ SP4 | 15/106 |
PZQ2 | 69/106 |
ART: (artesunate 100 mg/day) + S (sulfadoxine 250 mg/day) + P (pyrimethamine 12.5 mg/day) over three days;
PZQ (praziquantel 40 mg/kg once);
ART (artesunate 4 mg/kg/day over three days) + SP (sulfadoxine-pyrimethamine 25mg/kg );
ART(artesunate 4 mg/kg/day over three days) + S (sulfadoxine 25mg/kg) + P (pyrimethamine 12.5 mg/day).