Table 4. Artesunate prophylaxis trials focused on Schistosoma japonicum infections in endemic areas of China.

Citation	Year (trial)	Parasite	Location (Country)	Study Population(age)	Time point analysed (weeks)	N° of doses(interval in weeks)	Treatment	N° Positive/N° Treated
Wu et al., 1995 [34]	1993	S. japonicum	Jiangxi province	Residents (5–60)	4	8 (1)	ART1	0/346
							PBO	15/323
Xu et al., 1999 (study 1) [35]	1997	S. japonicum	Jiangxi province	Residents (6–65)	4	4 (2)	ART1	2/273
							PBO	11/289
Xu et al., 1999 (study 2) [35]	1997	S. japonicum	Jiangxi province	Residents (6–65)	4	4 (2)	ART1	0/107
							PBO	7/111
Li et al., 1999 [36]	1997	S. japonicum	Jiangxi province	Residents (5–60)	4	12 (2)	ART1	0/43
							PBO	4/58
Zhang et al., 2000 (study 1) [37]	1993	S. japonicum	Anhui province	Residents (6–65)	4	6 (2)	ART1	2/380
							PBO	18/400
Zhang et al., 2000 (study 2) [37]	1993	S. japonicum	Anhui province	Residents (6–65)	4	12 (2)	ART1	1/323
							PBO	31/323
Zhang et al., 2000 (study 3) [37]	1993	S. japonicum	Hubei province	Residents (6–65)	4	3 (1)	ART1	2/168
							PBO	22/200
Zhang et al., 2000 (study 4) [37]	1993	S. japonicum	Jiangxi province	Residents (6–65)	4	8 (1)	ART1	0/467
							PBO	41/397
Zhang et al., 2000 (study 5) [37]	1993	S. japonicum	Jiangxi province	Residents (6–65)	4	5 (2)	ART1	5/283
							PBO	20/304
Zhang et al., 2000 (study 6) [37]	1993	S. japonicum	Jiangxi province	Residents (6–65)	4	3 (2)	ART1	6/51
							PBO	12/64
Lu et al., 2000 (study 1) [38]	1999	S. japonicum	Anhui province	Residents (5–60)	4	3 (2)	ART1	0/210
							PBO	13/208
Lu et al., 2000 (study 2) [38]	1999	S. japonicum	Anhui province	Residents (5–60)	4	5 (2)	ART1	0/311
							PBO	17/312
Lu et al., 2000 (study 3) [38]	1999	S. japonicum	Anhui province	Residents (5–60)	4	13 (2)	ART1	1/209
							PBO	18/207

¹ART: artesunate (6 mg/kg); PBO: placebo.