Table 1. top overlapping prognostic genes identified from different breast cancer datasets.
| GSE 1456 | GSE 2034 | GSE 2990 | GSE 3494 | GSE 7390 | GSE 11121 | GSE 12093 | NKI 295 | |||||
| SCoR freq cutoff | 75 | 75 | 50 | 75 | 50 | 75 | 50 | 90 | ||||
| no. candidate prognostic genes | 495 | 249 | 53 | 247 | 101 | 429 | 63 | 651 | ||||
| genes in top 85 overlapping genes | 65 | 29 | 5 | 54 | 7 | 58 | 12 | 61 | ||||
| no. | top overlap genes | GSE 1456 | GSE 2034 | GSE 2990 | GSE 3494 | GSE 7390 | GSE 11121 | GSE 12093 | NKI 295 | freq. | prog. | function |
| 1 | CREBL2 | 1 | 1 | 1 | 1 | 4 | good | tumor suppressor | ||||
| 2 | CRIM1 | 1 | 1 | 1 | 3 | good | ||||||
| 3 | SPARCL1 | 1 | 1 | 1 | 3 | good | ||||||
| 4 | GLTSCR2 | 1 | 1 | 1 | 3 | good | tumor suppressor | |||||
| 5 | PDS5B | 1 | 1 | 1 | 3 | good | tumor suppressor | |||||
| 6 | CD302 | 1 | 1 | 1 | 3 | good | ||||||
| 7 | FBLN1 | 1 | 1 | 1 | 3 | good | tumor suppressor | |||||
| 8 | KIAA0494 | 1 | 1 | 1 | 3 | good | ||||||
| 9 | N4BP2L1 | 1 | 1 | 1 | 3 | good | ||||||
| 10 | SPTAN1 | 1 | 1 | 1 | 3 | good | ||||||
| 11 | CCNB2 | 1 | 1 | 1 | 1 | 1 | 5 | poor | proliferation | |||
| 12 | NUSAP1 | 1 | 1 | 1 | 1 | 1 | 5 | poor | proliferation | |||
| 13 | PRC1 | 1 | 1 | 1 | 1 | 1 | 5 | poor | proliferation | |||
| 14 | RACGAP1 | 1 | 1 | 1 | 1 | 1 | 5 | poor | proliferation | |||
| 15 | STMN1 | 1 | 1 | 1 | 1 | 1 | 5 | poor | proliferation | |||
| 16 | CDKN3 | 1 | 1 | 1 | 1 | 1 | 5 | poor | proliferation | |||
| 17 | KIF23 | 1 | 1 | 1 | 1 | 4 | poor | proliferation | ||||
| 18 | MELK | 1 | 1 | 1 | 1 | 4 | poor | proliferation | ||||
| 19 | MYBL2 | 1 | 1 | 1 | 1 | 4 | poor | proliferation | ||||
| 20 | PTTG1 | 1 | 1 | 1 | 1 | 4 | poor | proliferation | ||||
| 21 | RAD51 | 1 | 1 | 1 | 1 | 4 | poor | proliferation | ||||
| 22 | SPAG5 | 1 | 1 | 1 | 1 | 4 | poor | proliferation | ||||
| 23 | UBE2C | 1 | 1 | 1 | 1 | 4 | poor | proliferation | ||||
| 24 | BUB1 | 1 | 1 | 1 | 1 | 4 | poor | proliferation | ||||
| 25 | CCNA2 | 1 | 1 | 1 | 1 | 4 | poor | proliferation | ||||
| 26 | CENPF | 1 | 1 | 1 | 1 | 4 | poor | proliferation | ||||
| 27 | DLGAP5 | 1 | 1 | 1 | 1 | 4 | poor | proliferation | ||||
| 28 | H2AFZ | 1 | 1 | 1 | 1 | 4 | poor | |||||
| 29 | NEK2 | 1 | 1 | 1 | 1 | 4 | poor | proliferation | ||||
| 30 | SQLE | 1 | 1 | 1 | 1 | 4 | poor | |||||
| 31 | GINS2 | 1 | 1 | 1 | 1 | 4 | poor | proliferation | ||||
| 32 | RRM2 | 1 | 1 | 1 | 1 | 4 | poor | proliferation | ||||
| 33 | CIAPIN1 | 1 | 1 | 1 | 1 | 4 | poor | |||||
| 34 | NCAPG | 1 | 1 | 1 | 1 | 4 | poor | proliferation | ||||
| 35 | MLF1IP | 1 | 1 | 1 | 1 | 4 | poor | proliferation | ||||
| 36 | CTTN | 1 | 1 | 1 | 1 | 4 | poor | proliferation | ||||
| 37 | ESPL1 | 1 | 1 | 1 | 1 | 4 | poor | proliferation | ||||
| 38 | ZWINT | 1 | 1 | 1 | 1 | 4 | poor | proliferation | ||||
| 39 | CCNE2 | 1 | 1 | 1 | 1 | 4 | poor | proliferation | ||||
| 40 | CDC25A | 1 | 1 | 1 | 3 | poor | proliferation | |||||
| 41 | EXO1 | 1 | 1 | 1 | 3 | poor | proliferation | |||||
| 42 | FEN1 | 1 | 1 | 1 | 3 | poor | proliferation | |||||
| 43 | FOXM1 | 1 | 1 | 1 | 3 | poor | proliferation | |||||
| 44 | KIF2C | 1 | 1 | 1 | 3 | poor | proliferation | |||||
| 45 | MCM6 | 1 | 1 | 1 | 3 | poor | proliferation | |||||
| 46 | NCAPH | 1 | 1 | 1 | 3 | poor | proliferation | |||||
| 47 | ACOT7 | 1 | 1 | 1 | 3 | poor | ||||||
| 48 | C16orf61 | 1 | 1 | 1 | 3 | poor | ||||||
| 49 | C20orf24 | 1 | 1 | 1 | 3 | poor | ||||||
| 50 | CCNB1 | 1 | 1 | 1 | 3 | poor | proliferation | |||||
| 51 | GOT1 | 1 | 1 | 1 | 3 | poor | ||||||
| 52 | TACC3 | 1 | 1 | 1 | 3 | poor | proliferation | |||||
| 53 | DTL | 1 | 1 | 1 | 3 | poor | proliferation | |||||
| 54 | KPNA2 | 1 | 1 | 1 | 3 | poor | proliferation | |||||
| 55 | SHCBP1 | 1 | 1 | 1 | 3 | poor | proliferation | |||||
| 56 | C16orf80 | 1 | 1 | 1 | 3 | poor | ||||||
| 57 | COG4 | 1 | 1 | 1 | 3 | poor | proliferation | |||||
| 58 | SNRPA1 | 1 | 1 | 1 | 3 | poor | ||||||
| 59 | CDC20 | 1 | 1 | 1 | 3 | poor | proliferation | |||||
| 60 | DDX39 | 1 | 1 | 1 | 3 | poor | ||||||
| 61 | DHFR | 1 | 1 | 1 | 3 | poor | ||||||
| 62 | KIF20A | 1 | 1 | 1 | 3 | poor | proliferation | |||||
| 63 | CIAO1 | 1 | 1 | 1 | 3 | poor | proliferation | |||||
| 64 | KIAA0101 | 1 | 1 | 1 | 3 | poor | proliferation | |||||
| 65 | TOP2A | 1 | 1 | 1 | 3 | poor | proliferation | |||||
| 66 | TIMM17A | 1 | 1 | 1 | 3 | poor | ||||||
| 67 | PPFIA1 | 1 | 1 | 1 | 3 | poor | ||||||
| 68 | APRT | 1 | 1 | 1 | 3 | poor | ||||||
| 69 | NOL3 | 1 | 1 | 1 | 3 | poor | proliferation | |||||
| 70 | EBP | 1 | 1 | 1 | 3 | poor | proliferation | |||||
| 71 | H2AFX | 1 | 1 | 1 | 3 | poor | proliferation | |||||
| 72 | KIFC1 | 1 | 1 | 1 | 3 | poor | proliferation | |||||
| 73 | MAD2L1 | 1 | 1 | 1 | 3 | poor | proliferation | |||||
| 74 | NDUFS6 | 1 | 1 | 1 | 3 | poor | ||||||
| 75 | SNRPC | 1 | 1 | 1 | 3 | poor | ||||||
| 76 | SPC25 | 1 | 1 | 1 | 3 | poor | proliferation | |||||
| 77 | AURKA | 1 | 1 | 1 | 3 | poor | proliferation | |||||
| 78 | TMPO | 1 | 1 | 1 | 3 | poor | proliferation | |||||
| 79 | GTSE1 | 1 | 1 | 1 | 3 | poor | proliferation | |||||
| 80 | CENPM | 1 | 1 | 1 | 3 | poor | proliferation | |||||
| 81 | GINS1 | 1 | 1 | 1 | 3 | poor | proliferation | |||||
| 82 | KIF11 | 1 | 1 | 1 | 3 | poor | proliferation | |||||
| 83 | TAF11 | 1 | 1 | 1 | 3 | poor | ||||||
| 84 | CDC2 | 1 | 1 | 1 | 3 | poor | proliferation | |||||
| 85 | MKI67 | 1 | 1 | 1 | 3 | poor | proliferation |
“1” denotes that the gene is found by SCoR in this dataset. (a), Kaplan Meier plot of patient survival stratified by gender in stage II/III lung adenocarcinomas (top) or stage I lung adenocarcinomas (bottom) in GSE4716. (b), same as (a) except using data from GSE13213. (c), Kaplan Meier plot of lung adenocarcinoma recurrence stratified by patient gender using data from GSE25326. (d), Fisher exact test of patient survival vs. gender using a 2×2 contingency table and data from GSE28582.