Table 2. Predictive associations (percent significant and range of significant odds-ratios) of temporally primary pure lifetime estimated DSM-IV disorder types with the subsequent first onset of other estimated DSM-IV disorders based on the best-fitting multivariate survival model (n = 6,483)^a.

	Predictor disorders
Outcome disorders	Fear disorders		Distress disorders		Behavior Disorders		Substance disorders		Bipolar disorder		All disorders
	%g	ORsh	%g	ORsh	%g	ORsh	%g	ORsh	%g	ORsh	%g	ORsh
I. Fear disorders
Specific phobia	33.3	3.9	50.0	1.8-3.2	0	-	0	-	0	-	21.4	1.8-3.9
Agoraphobiab	66.7	4.8-9.2	50.0	2.8-3.3	0	-	0	-	0	-	28.6	2.8-9.2
Social phobia	66.7	3.6-4.2	50.0	1.8-2.1	0	-	0	-	0	-	30.8	1.8-4.2
Panic disorderc	33.3	3.3	25.0	3.1	0	-	0	-	0	-	14.3	3.1-3.3
II. Distress disorders
Separation anxiety disorder	50.0	2.4-2.7	66.7	2.4-4.7	0	-	0	-	0	-	28.6	2.4-4.7
Post-traumatic stress disorder	50.0	3.0-3.9	66.7	3.7-4.7	0	-	50.0	4.7	100.0	3.2	42.9	3.0-4.7
Major depressive episode/dysthymia	100.0	1.7-3.3	33.3	3.4	100.0	2.3-3.4	50.0	4.4	0	-	71.4	1.7-4.4
Generalized anxiety disorder	50.0	2.8-3.1	100.0	2.5-5.1	0	-	50.0	4.3	0	-	42.9	2.5-5.1
III. Behavior disorders
ADHD	0	-	0	-	66.7	3.7-5.6	0	-	0	-	20.0	3.7-5.6
Oppositional defiant disorder	75.0	1.9-2.9	50.0	2.0-3.6	66.7	2.3-4.9	0	-	0	-	50.0	1.9-4.9
Conduct disorder	50.0	1.8-3.4	25.0	4.4	66.7	2.3-3.0	50.0	10.3	0	-	42.9	1.8-10.3
Eating disordersd	50.0	2.4-3.7	50.0	2.5-3.8	66.7	2.2-4.1	0	-	0	-	42.9	2.2-4.1
IV. Substance disorders
Alcohol abusee	25.0	2.6	25.0	3.1	50.0	2.8-3.5	100.0	8.3	0	-	35.7	2.6-8.3
Drug abusee	50.0	2.4	25.0	2.1	75.0	2.8-6.1	100.0	8.4	100.0	3.2	57.1	2.1-8.4
V. Other disorders
Bipolar disorderf	75.0	2.8-4.3	50.0	1.8-5.7	100.0	2.3-4.4	0		0		64.3	1.8-5.7

^aBased on a discrete-time (person-year) survival model in which first lifetime onset of each of the 15 estimated DSM-IV disorders is predicted by 14 dummy variables for prior lifetime history of the other disorders, dummy variables for number of prior lifetime disorders (2-7+), and socio-demographic controls (sex, race/ethnicity, region of the country, urbanicity, parent education, number of biological parents with whom the adolescent lives, birth order, number of siblings, and age).

^bAgoraphobia is assessed with or without panic disorder

^cPanic Disorder is assessed with or without agoraphobia

^dIncludes anorexia nervosa, bulimia nervosa, and binge-eating disorder

^eWith or without dependence

^fIncludes Bipolar-I, Bipolar-II, and sub-threshold bipolar disorder

^gPercent of coefficients that are significant at the .05 level using two-sides design-based significance tests

^hRange of significant ORs