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Bethanechol treatment of SPL−/− mice leads to enhanced insulin secretion and reduced blood glucose levels. SPL−/− mice and WT littermates (freely fed 14-wk-old female mice) received a single dose of the muscarinic agonist, bethanechol (2 μg/g s.c.). Plasma insulin (A) and blood glucose (B) levels were measured at the indicated time points. Data are shown as means ± se (n=4/group). *P < 0.05 vs. corresponding WT values.
