Figure 9.

In vivo metabolic studies with SPL^−/− mice and WT littermates. A) Body weight. B) Total body composition (% fat mass and % lean mass). C) Freely-fed blood glucose levels. D) Fasting blood glucose levels. E) Fasting plasma insulin levels. F) Insulin tolerance test. G) Intravenous glucose tolerance test (IGTT). H) In vivo insulin release during the IGTT. All studies were carried out with 16- to 18-wk-old male littermates (n=5–7/group; for experimental details, see Supplemental Data). Data are expressed as means ± se. ***P < 0.001, **P < 0.01, *P < 0.05 vs. corresponding WT values.