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. 2012 May 9;32(19):6578–6586. doi: 10.1523/JNEUROSCI.6391-11.2012

Figure 5.

Figure 5.

Psychomotor sensitization and firing rate depression are occluded in T286D mice but rescued upon transgene inactivation. A, Psychomotor sensitization to cocaine is absent in T286D mice (WT SAL, n = 4; T286D SAL, n = 4; WT COC, n = 6; T286D COC, n = 6). B, Sample traces from T286D SAL and T286D COC at 120, 160, and 200 pA. C, A sensitizing regimen of cocaine (5 × 15 mg/kg) does not further decrease the firing rate depression in T286D mice (SAL, n = 14; COC, n = 21). D, Sample traces from T286D ON (transgene turned on) and T286D OFF (transgene turned off) at 100, 140, and 180 pA. E, Turning the transgene OFF re-establishes a normal firing rate. Inset, no differences in steady-state voltage responses to a series of current pulses between T286 ON (n = 9) and T286 OFF (n = 8). F, Turning the transgene OFF readjusts the A-type K+ current-regulated intrinsic excitability parameters, the latency to the first spike and interspike interval (at 160 pA; T286D ON, n = 9 cells; T286 OFF, n = 8 cells). G, Turning the transgene OFF rescues the psychomotor sensitization phenotype (T286D OFF SAL, n = 9; T286 OFF COC, n = 14). Calibration: 200 ms, 50 mV. Error bars indicate SEM. *p < 0.05.