Table 1.
Dog | Donor Marrow Cells × 108/kg | Weeks Between Marrow and Kidney Transplant | % Donor Chimerism at Kidney Transplant
|
RLI | Recipient G-Mobilized Leukocytes × 108/kg | % Donor Chimerism at End of Study (weeks)
|
Renal Graft Rejection (Weeks) | ||
---|---|---|---|---|---|---|---|---|---|
Grans | Lymphs | Grans | Lymphs | ||||||
G774 | 4 | 27 | 100 | 58.2 | Yes | 2.8 | 0 (204) | 0 (204) | No (204) |
G918 | 7.2 | 20 | 15 | 3.1 | Yes | 2.2 | 0 (193) | 0 (193) | No (193) |
H309 | 5.4 | 12 | 76.8 | 47.8 | Yes | 13 | 7.1 (70) | 20.1(70) | No (70) |
H128 | 3.5 | 15 | 87.3 | 36.8 | No | n/a | 0 (33) | 0 (33) | No (33) |
Dog H206 was mixed chimeric and received a transplanted kidney but had poor circulation 24 hours after surgery determined by Doppler ultrasound. The incision was reopened, the kidney repositioned, and circulation restored; however, after a double nephrectomy of the native kidneys serum creatinine levels indicated a nonfunctional transplanted kidney.