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. Author manuscript; available in PMC: 2013 Aug 28.
Published in final edited form as: Biochemistry. 2012 Aug 15;51(34):6860–6870. doi: 10.1021/bi300613e

Figure 8.

Figure 8

The reaction catalyzed by DHFR and the fits to KIEs from a series of active-site mutants (A), and a series of distal mutants (B). All fits correspond to the two-population model. Experimental data are from refs. 38, 39, and 67.