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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Bioorg Med Chem. 2012 Aug 8;20(19):5850–5863. doi: 10.1016/j.bmc.2012.07.052

Scheme 2.

Scheme 2

Groebke reaction using different amidines.

Reagents and conditions: i. MW, 400W, 110 °C, 30 min, HCl/dioxane, CH3CN.