Table 1.

Clinical characteristics of familial lone AF probands enrolled in the Vanderbilt AF Registry identified to have mutations or rare variants in ion channel or signaling proteins.

AF kindred and pedigree number	Age at onset (yr)	Age at diagnosis (yr)	Rhythm	Symptoms	Echo	LA size (mm)
AF 027
II-1	41	54	PerstAF	Yes	LVH	46
III-1	31	36	PAF	Yes	Normal	42
AF 063
II-1	33	39	PAF	Yes	Normal	44
II-2	41	48	PAF	Yes	Normal	42
AF 119
I-1	51	54	PerstAF	No	Normal	46
II-1	28	38	PAF	Yes	Normal	42
AF 240
II-1	70	72	PerstAF	No	LVH	50
III-1	42	42	PAF	Yes	Normal	43
III-2	39	42	PAF	Yes	Normal	42
AF 527
I-1	52	54	PerstAF	Yes	LVH	46
II-1	56	56	PAF	Yes	Normal	44
III-1	17	25	PAF	yes	Normal	42
AF 313
II-1	48	56	PermAF	Yes	MR; LVH	52
II-1	44	46	PerstAF	Yes	Normal	42
II-2	42	43	PAF	Yes	Normal	41
II-4	44	45	PAF	Yes	Normal	42
AF 579
I-1	56	64	PerstAF	No	LVH	46
II-2	48	49	PAF	Yes	Normal	43
II-3	49	50	PAF	No	Normal	41
AF 673
II-1	48	50	PAF	Yes	Normal	41
AF 242
II-1	38	40	PAF	Yes	Normal	44
II-9	42	44	PAF	Yes	Normal	43
III-2	20	26	PAF	Yes	Normal	39
AF 406
I-1	78	78	PermAF	No	LVH	48
II-4	61	62	PerstAF	No	LVH	49
II-5	52	58	PAF	Yes	Normal	46
III-1	17	22	PAF	Yes	Normal	39
III-3	39	42	PAF	Yes	Normal	42
III-5	42	46	PAF	Yes	Normal	44
III-7	44	45	PAF	Yes	Normal	46
AF 1111
I-1	58	64	PermAF	No	LVH	50
II-4	56	60	PAF	Yes	Normal	44
II-5	46	48	PAF	Yes	Normal	45

PAF = paroxysmal atrial fibrillation; Perst = persistent; Perm = permanent; LA = left atrial; LVH = left ventricular hypertrophy; MR = mitral regurgitation.