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An interaction between rare (ion channel and non-ion channel) and common genetic variants to determine susceptibility to the development of familial AF.
| AF by age 50 yrs | No AF by age 50 yrs | |
|---|---|---|
| Chr4q25 SNPs absent | 0 | 13 |
| Chr4q25 SNPs present | 21 | 8* |
P = 1.21 × 10−5 comparing presence of both common and rare variants in 11 kindreds with familial AF.
Chr,chromosome; SNPs, single nucleotide polymorphisms.
