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. Author manuscript; available in PMC: 2012 Sep 25.
Published in final edited form as: J Am Coll Cardiol. 2012 Jul 18;60(13):1173–1181. doi: 10.1016/j.jacc.2012.04.030

Table 4.

Genetic association between common and rare variants un-stratified and stratified by age of onset and age of unaffected individuals in the families.

Sample
size		 Presence of both
common and rare
variants		 OR (95% CI) Permutation
P-value
Un-stratified 70 P = 9.21 × 10−10 53 (10–273) <0.001
Age of onset <50 yrs 64 P = 9.41 × 10−8 39 (8–205) <0.001
Age of onset <40 yrs 57 P = 4.13 × 10−6 51 (6–452) <0.001
Unaffected age >50 yrs 48 P = 8.63 × 10−7 41 (7–239) <0.001
Age of onset <50 yrs,
Unaffected age >50 yrs		 42 P = 1.21 × 10−5 31 (5–179) <0.001
Age of onset <40 yrs,
Unaffected age >50 yrs		 35 P = 1.62 × 10−4 40 (4–385) <0.001

OR, odds ratio; CI, confidence interval.