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P. gingivalis-specific Ab isotypes IgG1, IgG2b, IgG2c, and IgG3. P. gingivalis-specific IgG production in uninfected ApoE−/− (n = 15), P. gingivalis-infected ApoE−/− (n = 21), uninfected ApoE−/−TLR4−/− (n = 17), and P. gingivalis-infected ApoE−/−TLR4−/− (n = 14) mice as measured by ELISA. (A) IgG1, (B) IgG2b, (C) IgG2c, and (D) IgG3. White squares, uninfected; gray squares, P. gingivalis infected. Data were analyzed by Student t test. *p < 0.05, **p = 0.0092.
