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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: J Immunol. 2012 Sep 5;189(7):3759–3766. doi: 10.4049/jimmunol.1201529

FIGURE 2. Profiling of antibody responses in cancer patients to CTLA-4 blockade and GM-CSF with protein microarrays.

FIGURE 2

(A) Unsupervised clustering of median centered log2 transformed and normalized fluorescence intensities in pre-treatment and post-treatment sera of 11 evaluable patients binding to proteins spotted on the arrays. Responders are highlighted in red and non-responders in black. (B) Venn diagram showing the number of up-modulated antibodies that are shared (shown by number in overlaps) or are unique in the 11 patients. Responders are represented by pink circles and non-responders in blue. Sizes of circles approximate the number of antigens.