TABLE II.
Odds Ratiosa and Confidence Intervals for Associations Between Maternal and Inherited SNPs in Folate Related Genes and NTD Risk in Offspring, California, 1999–2003
| SNP rs ID | Referent Genotype | Maternal Model | Infant Model | ||||
|---|---|---|---|---|---|---|---|
|
| |||||||
| ORs and CIs | ORs and CIs | ||||||
|
| |||||||
| Genotypeb | G-E c | Interaction Effectd | Genotypeb | G-E c | Interaction Effectd | ||
| DHFR | |||||||
| rs1650723 | GG | 0.41e 0.12, 1.41 |
-- | -- | 0.96f 0.52, 1.76 |
-- | -- |
| rs1677693 | CC | 0.72e 0.35, 1.46 |
-- | -- | 0.98 0.66, 1.45 |
-- | -- |
| rs11951910 | TT | 1.18 0.66, 2.13 |
-- | -- | 0.85 0.42, 1.72 |
-- | -- |
| MTHFD1 | |||||||
| rs745686 | AA | 0.81e 0.42, 1.56 |
-- | -- | 1.26e 0.65, 2.44 |
-- | -- |
| rs8011839 | CC | 1.07 0.72, 1.60 |
-- | -- | 1.14 0.80, 1.62 |
-- | -- |
| rs1076991 | AA | 0.94 0.68, 1.28 |
-- | -- | 1.14 0.84, 1.54 |
-- | -- |
| rs1885031 | AA | 1.50 0.96, 2.35 |
-- | -- | N/Ag | ||
| rs1950902 | CC | 0.91 0.53, 1.54 |
-- | -- | 0.85 0.52, 1.40 |
-- | -- |
| rs2236224 | CC | 1.50e 0.83, 2.72 |
-- | -- | 1.02 0.83, 1.26 |
0.44 0.24, 0.80 |
1.58 0.99, 2.51 |
| rs2236225 | CC | N/Ag | 0.90 0.73, 1.10 |
0.48 0.27, 0.86 |
1.53 0.95, 2.47 |
||
| rs3783728 | TT | 0.42e 0.11, 1.62 |
-- | -- | 0.51 0.21, 1.23 |
-- | -- |
| rs11158542 | TT | 0.91e 0.49, 1.69 |
-- | -- | 0.80e 0.16, 3.99 |
-- | -- |
| rs11627387 | GG | 0.76e 0.41, 1.41 |
-- | -- | 1.11 0.87, 1.41 |
7.81 3.33, 16.67 |
4.25 2.33, 7.75 |
| rs11849530 | AA | 0.88e 0.40, 1.91 |
-- | -- | 0.79e 0.36, 1.75 |
-- | -- |
| rs34616731 | TT | 1.02e 0.62, 1.68 |
-- | -- | 1.38e 0.87, 2.17 |
-- | -- |
| MTHFR | |||||||
| rs1476413 | GG | 1.30 0.99, 1.71 |
0.31 0.10, 0.95 |
0.55 0.20, 1.48 |
1.22 0.74, 2.00 |
-- | -- |
| rs1801131 | AA | 1.33 1.03, 1.73 |
0.30 0.11, 0.81 |
0.58 0.24, 1.43 |
N/Ag | ||
| rs1801133 | CC | 0.74 0.59, 0.91 |
3.33 1.59, 7.14 |
0.69 0.41, 1.17 |
0.66e 0.29, 1.47 |
-- | -- |
| SHMT1 | |||||||
| rs669340 | CC | 0.69 0.49, 0.96 |
-- | -- | 1.10 0.81, 1.49 |
-- | -- |
| rs1979277 | GG | N/Ag | 0.78 0.55, 1.12 |
-- | -- | ||
| rs2168781 | CC | 1.15 0.84, 1.59 |
-- | -- | 0.87 0.65, 1.16 |
-- | -- |
| rs2273026 | GG | 1.06 0.68, 1.68 |
-- | -- | N/Ag | ||
| rs9909104 | TT | 1.00e 0.62, 1.60 |
-- | -- | 1.03 0.83, 1.29 |
-- | -- |
| rs12939757 | AA | 1.44e 0.78, 2.66 |
-- | -- | 1.68 1.34, 2.09 |
0.46 0.25, 0.86 |
2.01 1.20, 3.37 |
| rs12952556 | TT | N/Ag | 0.88 0.70, 1.10 |
-- | -- | ||
| TYMS | |||||||
| rs502396 | TT | 0.93 0.77, 1.12 |
0.51 0.28, 0.89 |
0.91 0.53, 1.56 |
N/Ag | ||
| rs699517 | CC | 0.99 0.79, 1.25 |
0.46 0.21, 1.01 |
0.70 0.38, 1.29 |
0.75 0.55, 1.03 |
-- | -- |
| rs1001761 | CC | 0.68e 0.37, 1.25 |
-- | -- | N/Ag | ||
| rs2847153 | GG | 0.94 0.61, 1.44 |
-- | -- | 0.95 0.74, 1.23 |
0.41 0.18, 0.93 |
0.73 0.37, 1.45 |
| rs2847149 | GG | 0.76 e 0.42, 1.39 |
-- | -- | N/Ag | ||
| rs2847326 | TT | 0.88 0.61, 1.26 |
-- | -- | 0.87f 0.59, 1.30 |
-- | -- |
CI, confidence interval; G-E, gene-environment; OR, odds ratio.
Estimated using logistic regression. ORs and CIs (below) are given for evaluated parameters. The referent groups are non-Hispanic Whites and the high folate intake group.
ORs and 95% CIs (below) are given for heterozygotes estimated by a linear (additive) genetic model where the likelihood ratio test for G-E interaction P value ≥ 0.20.
G-E ORs and 80% CIs (below) represent the log odds derived from the interaction parameter from the logistic model. ORs are reported for all model parameters where the likelihood ratio test for G-E interaction P value < 0.20, otherwise “--“ is shown.
For models with a significant G-E estimate, interaction effect ORs were calculated by exponentiating the sum of the gene, folate, and interaction coefficients and represent the risk of NTDs in low folate heterozygotes compared to high folate common homozygotes, otherwise “--“ is shown.
Non-Hispanic Whites only included in this model.
Hispanics only included in this model.
N/A specified for models in which controls were shown to deviate from Hardy-Weinberg Equilibrium at the corresponding SNP.