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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Chem Biol Drug Des. 2012 Jul 23;80(4):631–637. doi: 10.1111/j.1747-0285.2012.01428.x

Figure 1.

Figure 1

Chemical structures of nutlin 2 and nutlin 3. Nutlin 2 structure was taken from a co-crystal structure of nutlin 2 with the MDM2 N-terminal binding domain. Nutlin 3a-CM was created from nutlin 2 structure and energy minimized within 1RV1.