TABLE 3.
Age Adjusted Odds Ratios and 95% Confidence Intervals for the Joint Effect of Body Size and Recreational Physical Activity among Postmenopausal Women on Breast Cancer Risk in the Long Island Breast Cancer Study Project (1996–1997)
| Recreational Physical Activity (average hours per week) |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Body Size Measurement |
Ca/Co |
No RPA |
Ca/Co |
Low RPA |
ICR (95% CI) |
Ca/Co |
High (RPA) |
ICR (95% CI) |
|||
| OR | 95% CI | OR | 95% CI | OR | 95% CI | ||||||
| Weight gain since age 20 (kg) in relation to lifetime RPA (Postmenopausal women: Total Ca/Co = 927/917) | |||||||||||
| Maintain | 26/24 | 1.00 | reference | 30/44 | 0.70 | (0.33,1.46) | 37/41 | 0.97 | (0.47,1.99) | ||
| Lose | 13/13 | 1.05 | (0.40,2.76) | 12/25 | 0.48 | (0.20,1.18) | −0.27 (−2.08,1.54) | 7/21 | 0.31 | (0.11,0.88) | −0.71 (−2.50,1.09) |
| Low gain | 90/78 | 1.19 | (0.62,2.27) | 144/150 | 1.03 | (0.56,1.90) | 0.14 (−1.75,2.03) | 132/138 | 0.99 | (0.54,1.84) | −0.16 (−2.21,1.88) |
| High gain | 126/106 | 1.28 | (0.68,2.39) | 151/109 | 1.48 | (0.79,2.75) | 0.50 (−1.72,2.72) | 159/168 | 1.02 | (0.55,1.87) | −0.23 (−2.31,1.86) |
| p for multiplicative interaction | 0.033 | ||||||||||
| Weight gain since menopause (kg) in relation to postmenopausal RPA (Postmenopausal women: Total Ca/Co = 795/743) | |||||||||||
| Maintain | 39/44 | 1.00 | reference | 59/72 | 0.94 | (0.54,1.63) | 41/54 | 0.85 | (0.47,1.54) | ||
| Lose | 48/37 | 1.39 | (0.75,2.57) | 50/51 | 1.02 | (0.57,1.83) | −0.31 (−2.17,1.56) | 33/49 | 0.66 | (0.35,1.24) | −0.58 (−2.21,1.06) |
| Low gain | 64/55 | 1.27 | (0.72,2.24) | 85/74 | 1.23 | (0.72,2.11) | 0.03 (−1.81,1.87) | 75/94 | 0.84 | (0.49,1.44) | −0.27 (−1.87,1.33) |
| High gain | 93/61 | 1.57 | (0.91,2.72) | 112/78 | 1.48 | (0.87,2.52) | −0.02 (−2.12,2.07) | 96/74 | 1.35 | (0.79,2.32) | −0.07 (−2.09,1.96) |
| p for multiplicative interaction | 0.646 | ||||||||||
| BMI at reference date (kg/m2) in relation to postmenopausal RPA (Postmenopausal women: Total Ca/Co = 832/790) | |||||||||||
| < 18.5 | 4/6 | 0.55 | (0.15,2.07) | 3/4 | 0.70 | (0.15,3.32) | 3/7 | 0.34 | (0.08,1.40) | ||
| 18.5–24.99 | 91/83 | 1.00 | reference | 127/140 | 0.84 | (0.57,1.23) | 0.31 (−1.54,2.17) | 93/115 | 0.73 | (0.48,1.09) | 0.07 (−0.94,1.07) |
| 25.0–29.99 | 75/66 | 1.02 | (0.65,1.60) | 121/87 | 1.26 | (0.84,1.89) | 0.40 (−0.74,1.53) | 94/98 | 0.85 | (0.56,1.29) | 0.10 (−0.86,1.06) |
| ≥ 30.0 | 79/62 | 1.17 | (0.74,1.83) | 73/57 | 1.17 | (0.74,1.86) | 0.17 (−0.96,1.30) | 69/65 | 0.99 | (0.62,1.55) | 0.09 (−1.10,1.29) |
| p for multiplicative interaction | 0.454 | ||||||||||
Ca, cases; Co, controls; OR, odds ratio; 95% CI, 95% confidence interval; RPA, recreational physical activity; ICR, interaction contrast ratio
Weight loss: < −3kg; Weight Maintenance: +/− 3kg; Weight gain: > +3kg