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. 2012 Jul 5;51(10):1881–1886. doi: 10.1093/rheumatology/kes162

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© The Author(s) 2012. Published by Oxford University Press on behalf of The British Society for Rheumatology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 1 — Enrichment of Th1 cells and proportion of IL-17-producing CD4⁺ T cells and CD3⁺CD4⁻ T cells in the peripheral blood of sJIA patients.

Proportions of (A) IFNγ- and (B, top left panel) IL-17-producing CD4⁺ T cells in PBMCs from sJIA patients, oligoarticular JIA patients, age-matched paediatric control subjects and healthy adult control subjects. Horizontal bars show median values. Shown in the right panel (A and B) are representative dot plots from PBMCs of sJIA patients at disease flare and remission (quiescent), from age-matched paediatric controls and healthy adult controls. The cells were gated on CD3. The bottom left of Figure 1B shows the proportion of IL-17-producing CD3⁺CD4⁻ T cells in PBMCs from sJIA patients and age-matched paediatric control subjects; IL-17-producing CD3⁺CD4⁻ T cells in PBMCs from oligoarticular JIA patients are not available for comparison.