Table 1.
Physical and echocardiographic data in sham-operated and HF rats at the end of the study period
| Sham-operated | HF/control | HF/Bisoprolol | |
|---|---|---|---|
| Physical data | |||
| BW (kg) | 0.463 ± 0.014 | 0.446 ± 0.010 | 0.470 ± 0.013 |
| HW (g) | 1.15 ± 0.04 | 1.40 ± 0.02* | 1.28 ± 0.04*† |
| HW/BW (g·kg−1) | 2.50 ± 0.08 | 3.14 ± 0.12* | 2.73 ± 0.09*† |
| Echocardiography | |||
| HR (bpm) | 333.9 ± 11.1 | 332.4 ± 4.66 | 287.5 ± 7.28& |
| LV EF (%) | 67.1 ± 0.9 | 26.3 ± 1.2* | 35.5 ± 1.7*† |
| LVIDd (mm) | 8.27 ± 0.17 | 10.95 ± 0.13* | 9.97 ± 0.15*† |
| LVIDs (mm) | 5.14 ± 0.16 | 9.51 ± 0.16* | 8.18 ± 0.20*† |
| LVAWDd (mm) | 1.72 ± 0.03 | 1.46 ± 0.05* | 1.45 ± 0.06* |
| LVPWDd (mm) | 1.68 ± 0.06 | 2.02 ± 0.06* | 2.17 ± 0.08*† |
| Infarct size (%) | – | 44.8 ± 3.7 | 45.2 ± 4.3 |
anova analysis and Bonferroni test were used among all three groups. Data are presented as mean ± SEM. *P < 0.05 versus Sham; †P < 0.05 versus HF/control, &P < 0.05 versus Sham and HF/control.
BW = body weight, HW = heart weight, HR = heart rate, LV EF = LV ejection fraction, LVIDd = LV internal diameter at diastole, LVIDs = LVID at systole, LVAWDd = LV anterior wall diameter at diastole, LVPWDd = LV posterior wall diameter at diastole.