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. 2012 Sep;167(1):13–22. doi: 10.1111/j.1476-5381.2012.02018.x

Table 3.

Activators of TRPA1 related to oxidative stress

Compound EC50 Reference
4-hydroxy-2-nonenal (4-HNE) 10–27 µM Trevisani et al. (2007); Macpherson et al. (2007b); Andersson et al. (2008); Taylor-Clark et al. (2008)
4-oxo-nonenal (4-ONE) 1.5–1.9 µM Andersson et al. (2008); Taylor-Clark et al. (2008)
4-hydroxyhexenal (4-HHE) 39–50 µM Andersson et al. (2008); Taylor-Clark et al. (2008)
Hydrogen peroxide (H2O2) 230 µM Andersson et al. (2008)
15-deoxy-delta(12,14)-prostaglandin J(2) [15d-PGJ(2) ] 5.6 µM Andersson et al. (2008)