Figure 4.
Motor impulsivity evaluation (ineffective responding) in DBA/2 mice treated with pregabalin (10, 20 or 40 mg·kg−1, p.o., for 10 days and 1 h before testing) or topiramate (12.5, 25 or 50 mg·kg−1, p.o., for 10 days and 1 h before testing) in the DRT. Dots represent the means and vertical lines ± SEM of number of lever presses in the immediate lever during delay onset with pregabalin (A) or topiramate (B) treatment. *Values for topiramate 50 mg·kg−1 group that are significantly different (P < 0.05) from its corresponding vehicle group; **values for topiramate 25 mg·kg−1 group that are significantly different (P < 0.05) from its corresponding vehicle group; #values for topiramate 12.5 mg·kg−1 group that are significantly different (P < 0.05) from its corresponding vehicle group.