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. 2012 Sep;167(1):222–232. doi: 10.1111/j.1476-5381.2012.01982.x

Figure 3.

Figure 3

Kinetics of the oxidation of phospho-ibuprofen (PI) or ibuprofen by CYPs. Equimolar phospho-ibuprofen (A) or ibuprofen (B) at 150 µM was incubated with individual human CYP isoforms and NADPH-regenerating solution at 37°C for up to 20 h. The oxidized products were extracted at the designated time points and assayed by HPLC. Values are mean ± SEM.