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Kinetics of the oxidation of phospho-sulindac (PS) by CYPs. Phospho-sulindac at 100 µM was incubated with individual human CYP isoforms and NADPH-regenerating solution at 37°C for up to 20 h. The oxidized products were extracted at the designated time points and analysed by HPLC. Values are mean ± SEM.
