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Induction of ROS by phospho-ibuprofen (PI) or ibuprofen. Equimolar phospho-ibuprofen or ibuprofen at 150 µM was incubated with CYP3A4 (A) or BNPP-treated HLM (B) for 1 h, and ROS were determined as described in Methods. Values are mean ± SEM. *, P < 0.01.
