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Lipophilicity (LogP), modelling prediction and experimental results on the metabolism of phospho-ibuprofen, phospho-sulindac and the parent NSAIDs by human CYPs
| Human CYP isoforms | |||
|---|---|---|---|
| Compound | LogP | Prediction | Experimental |
| Phospho-ibuprofen | 5.4 | 2C19, 3A4 | 1A2, 2C19, 2D6, 3A4 |
| Ibuprofen | 3.8 | 1A2, 2C9, 2C19 | 2C9 |
| Phospho-sulindac | 3.9 | 3A4 | 1A2, 2C9, 2C19, 2D6, 3A4 |
| Sulindac | 2.3 | 1A2, 2C9 | None |
LogP (P is octanol–water partition coefficient) is determined using ChemDraw 7.0.
