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. Author manuscript; available in PMC: 2013 Sep 11.
Published in final edited form as: Circulation. 2012 Sep 11;126(11 Suppl 1):S38–S45. doi: 10.1161/CIRCULATIONAHA.111.083451

Figure 3.

Figure 3

Figure 3

AAA formation is attenuated in IL-17−/− and IL-23−/− mice. A. Infrarenal mouse aortas were perfused with elastase (0.4U/mL) or heat-incativated elastase (control), and aortic diameter was measured on days 3, 7 and 14. The abdominal aorta (Day 0, first panel, represented by white arrows) was significantly increased in diameter after elastase-perfusion of WT mice (Day 14, last panel, represented by black arrows). B. A representative AAA dissected from an elastase-perfused WT mouse on day 14. C. Elastase-perfused WT mice had no significant change in aortic diameters on days 3 and 7 compared to controls. On day 14, aortic diameter was significantly increased in elastase-perfused WT mice compared to controls. D. A significant decrease in aortic diameter occurred in elastase-perfused IL-17−/− and IL-23−/− mice compared to elastase-perfused WT mice. n=6–9 animals/group; *p<0.05 vs. corresponding controls; #p<0.05 vs. elastase-perfused WT mice.