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IL-17 modulates ASMC activation. Transient treatment of ASMCs with elastase (5 min) or recombinant IL-17 (10ng/ml) was performed, and cytokine measurement was done after 24hr or 48hr. A significant increase in IL-6, MCP-1, KC, MIP-1α RANTES and TNF-α occurred in elastase-treated or IL-17-treated ASMCs compared to controls. n=8/group; *p<0.05 vs. controls.
