Table 2.

List of Brain Proteins with Differential Levels in M631L Transgenic Mice Relative to J20 Transgenic Mice

Spot	Protein identified	Accession #	Coverage	Number of identified peptidesa	Score	MW (kDa)	pI	P valueb	Fold changec
1	Brain acid soluble protein 1 (BASP1)	Q91XV3	47.79	5	38.4	22.1	4.51	0.008	3.34↑
2	V-type proton ATPase subunit B (VATB2)	P62814	20.74	8	77.9	56.5	5.81	0.007	9.19↑
3	ATP synthase subunit α, mitochondrial (ATPα)	Q03265	43.40	19	410.2	59.7	9.19	0.003	1.17↑
4	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)	P16858	12.31	4	38.8	35.8	8.25	0.01	0.70↓
5	Voltage-dependent anion-selective channel protein 1 (VDAC-1)	Q60932	21.96	5	42.5	32.3	8.43	0.03	0.76↓
6	Glutathione S-transferase Mu 1 (GSTM1)	P10649	20.64	4	27.1	26.0	7.94	0.039	0.57↓
7	Peptidyl-prolyl cis-trans isomerase 1 (Pin-1)	P17742	10.98	2	19.4	18	7.90	0.018	0.608↓
8	Peptidyl-prolyl cis-trans isomerase 1 (Pin-1)	P17742	17.68	3	10.2	18	7.90	0.018	0.608↓
9	Ubiquitin-conjugation enzyme E2N (EBE2N)	P61089	17.11	2	16.1	17.1	6.57	0.034	9.17↑
10	Phosphaditylethanolamine binding-protein 1 (PEBP-1)	P70296	28.34	3	30.2	20.82	5.07	0.0008	2.97↑
11	Carbonic anhydrase-2 (CA-2)	P00920	16.15	2	20.2	59.7	6.54	0.002	0.60↓
12	Phosphoglycerate mutase 1 (PGM1)	Q9DBJ1	25.98	3	30.2	28.81	6.79	0.004	0.72↓
13	Superoxide dismutase (Mn), mitochondrial (SOD2)	P09671	6.31	1	10.1	24.0	8.8	0.037	0.76↓
14	Triose phosphate isomerase (TPI)	P17751	41.37	6	60.1	26.7	7.07	0.009	0.69↓

^aThe number of peptide sequences identified by nanospray ESI-MS/MS of tryptic peptides.

^bThe fold change in spot density from M631L Tg mice compared with J20 Tg mice. The arrow indicates the direction of change.

^cThe P-value associated with fold change^b calculated using a Student's t-test.