FIG. 6.

Oxidation sites of lipid-free human apoAI. Many of these sites are located near hinge regions that may be important for rearrangement upon lipid association and subsequent binding to ABCA1 for reverse cholesterol transport activity. Lys-195 facilitates chlorination of Tyr-192. Image derived from the crystal structure stored in the Protein Data Bank (2); accession code 2A01. Figure generated using Protein Workshop (22).