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Venn diagram of HNE-modified proteins identified during the progression of AD. Alpha-enolase and ATP synthase are the common targets of oxidative modification between AD, MCI, and EAD, and oxidative modification of these proteins might be key in the progression and pathogenesis of AD. AD, Alzheimer disease; EAD, early AD; MCI, mild cognitive impairment. (To see this illustration in color the reader is referred to the web version of this article at www.liebertonline.com/ars.)
