FIG. 15.

Nitrated proteins identified during the progression of AD in the hippocampus¹ and IPL² regions. DRP2 and aldolase are common targets of nitration between MCI and EAD. The identification of α-enolase as the only common target of protein nitration in AD, MCI, and EAD suggest that nitration of enolase might be critical to the progression and pathogenesis of AD. DRP2, dihydropyrimidinase-related protein 2; IPL, inferior parietal lobule. (To see this illustration in color the reader is referred to the web version of this article at www.liebertonline.com/ars.)