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. Author manuscript; available in PMC: 2013 Jul 20.
Published in final edited form as: J Org Chem. 2012 Jul 3;77(14):6051–6058. doi: 10.1021/jo3008435

Figure 1.

Figure 1

Conversion of KAPA to DAPA catalyzed by BioA. DAPA is elaborated to biotin by two additional enzymes (BioD and BioB), then covalently attached to biotin carboxylase carrier protein domains (BCCP) by an ATP-dependent biotin protein ligase.