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. Author manuscript; available in PMC: 2013 Aug 14.
Published in final edited form as: Biochemistry. 2012 Aug 2;51(32):6328–6341. doi: 10.1021/bi300942x

Figure 9.

Figure 9

Model of Alk1 bound to BMP-9 (A) Alk1 (green) bound to BMP-9 (pink ribbon with surface). Alk3 (purple) is overlaid according to the manner by which it binds to BMP-2 in the Alk3:BMP-2 crystal structure (19). (B) Model of Alk1 (green) bound to BMP-9 (pink) as determined using RosettaDock (right) or by positioning Alk1 as Alk3 is positioned onto BMP-2 (left). Extent of pink shading on the ligand surface and yellow color on the receptor ribbon corresponds to the severity of the clashes. (C) Stereoview of Alk1:BMP-9 complex in which Alk1 is bound in an Alk3-like manner (same as panel B, left). Extent of pink shading on BMP-9 and yellow color on Alk1 corresponds to the severity of the clashes. Sidechains of Alk1 (green labels) and BMP-9 (magenta labels) which clash are shown. (D) Interface of the RosettaDock derived Alk1:BMP-9 complex. Alk1 residues are shaded green; BMP-9 residues are shaded pink. Clashes depicted in panel B were calculated using the clash function within the program Chimera (58).