Table 2.
Overview of neurodegenerative changes with age in selected primate species (in order of lifespan)
| Dendritic atrophy | Neuron loss | Diffuse amyloid | Tauopathy | AD | |
|---|---|---|---|---|---|
| Human, clinically normal | ++ | ± | + | ++ after 80 | +++ after 80 |
| Great apea | ? | ? | + | ± | – |
| Baboon | ++ after 20 | ? | |||
| Rhesus monkey | ++ | +? | ++ | – | – |
| Squirrel monkey | ++ | ? | ++ | – | – |
| Marmoset | ? | ? | ++ | – | ? |
| Mouse lemur | ? | ? | ++ | ++ | ? |
aChimpanzee, 41 years (Rosen et al. 2008), 59 years (Gearing et al. 1994, 1996), and 2 “aged,” no age given (Gearing et al. 1994); gorilla, 44 years (Kimura et al. 2001); orangutans—28, 31, and 36 years (Gearing et al. 1997); baboon (Schultz et al. 2000); and lemur (Bons et al. 2006; Kraska et al. 2011; Marchal et al. 2012)