Fig. 2.

Abasic site incision activity does not correlate with MLSP. a Representative gel showing incision of an oligonucleotide containing a THF abasic site analog (see Table 2) by a cow liver nuclear extract. Control oligo is THF control (Table 2). b–c No correlation between MLSP and abasic site incision activity of b brain and c liver nuclear extracts. d Residual analysis of brain APE activity and animal MLSP showing no significant correlation. e FIC analysis (see “Materials and methods”) of brain APE activity and MLSP showing no significant correlation. Values are natural log transformations of data from Tables 1 and 4