Fig. 1.

IgE levels are elevated in Socs1^−/−Ifnγ^−/− mice. (A) Serum IgE in C57BL/6, mice lacking IFN-γ (Ifnγ^−/−), and mice lacking both SOCS1 and IFN-γ (Socs1^−/−Ifnγ^−/−). Mice were untreated, subjected to antigen sensitization and challenge (OVA) or treated with Alum alone (Saline) (n ≥ 7). (B) Serum IgG₁ levels in C57BL/6, Ifnγ^−/− and Socs1^−/−Ifnγ^−/− mice. Mice were subjected to antigen sensitization and challenge (OVA) or treated with Alum alone (Saline) (n=4). (C) Antigen-specific total IgG was detected by ELISA in OVA-challenged C57BL/6, Ifnγ^−/− and Socs1^−/−Ifnγ^2−/− mice. Bars represent mean ± standard deviation. ND: Not detected. ** p < 0.0001