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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Arthritis Rheum. 2012 Oct;64(10):3119–3128. doi: 10.1002/art.34544

Figure 2. TNFα contributes to the IFN signature in RA synovial fluid Mϕ.

Figure 2

CD14+ Mϕ from SF of 18 patients with RA and 13 patients with SpA were cultured o/n in the presence of IgG1 or etanercept (10 mg/ml) (A-C). D, Mϕ from blood were cultured with TNFα in the presence or absence of anti-IFNα, anti-IFNβ or both. The expression of IFIT1 mRNA (A), MX1 mRNA (B) and CXCL10 mRNA (C, D) was measured using real-time PCR and normalized relative to GAPDH mRNA. The Friedman test followed by post-hoc analysis with the Wilcoxon matched-pairs signed rank test was used for statistical analysis. C, CXCL10 protein amounts in the culture supernatants of RA SF Mϕ were measured using ELISA. A Wilcoxon matched-pairs signed rank test was used for statistical analysis. (*=p<0.05, **=p<0.01, ***=p<0.001)

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