TABLE 1.
Absolute mM whole-VOI tissue concentrations (VOI), global WM and GM concentrations (CWM, CGM) of the NAA, Cho, Cr, mI for the 18 subjects, using Eqs. [3], Eq. [4] and least-squares fitting. The global fitting error (Eik in Eq. [5]) per voxel (divided by the number of terms in the sum) were calculated for each patient and metabolite, and averaged over all patients.
| Concentrations [mM] | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| NAA | Cr | Cho | mI | |||||||||
| subject | VOI | CWM | CGM | VOI | CWM | CGM | VOI | CWM | CGM | VOI | CWM | CGM |
| 1 | 7.2 | 7.1 | 8.0 | 5.4 | 4.9 | 6.4 | 1.4 | 1.5 | 1.1 | 4.6 | 4.2 | 5.4 |
| 2 | 8.3 | 8.3 | 9.3 | 6.7 | 5.0 | 7.3 | 1.4 | 1.5 | 1.3 | 4.3 | 3.9 | 5.3 |
| 3 | 7.9 | 7.9 | 9.1 | 5.9 | 4.9 | 8.1 | 1.3 | 1.4 | 1.3 | 4.8 | 4.6 | 5.7 |
| 4 | 7.5 | 7.5 | 8.4 | 5.1 | 4.3 | 6.7 | 1.2 | 1.3 | 1.2 | 4.6 | 4.1 | 5.8 |
| 5 | 7.6 | 7.2 | 9.0 | 5.0 | 4.5 | 6.2 | 1.3 | 1.4 | 1.3 | 4.9 | 4.8 | 5.4 |
| 6 | 7.7 | 7.7 | 8.3 | 5.4 | 4.9 | 6.6 | 1.3 | 1.4 | 1.3 | 5.8 | 5.5 | 6.5 |
| 7 | 7.0 | 6.6 | 8.0 | 5.0 | 4.3 | 6.0 | 1.0 | 1.0 | 1.1 | 4.2 | 4.0 | 4.7 |
| 8 | 7.1 | 7.7 | 7.3 | 4.6 | 4.4 | 5.5 | 1.2 | 1.3 | 1.1 | 6.0 | 5.9 | 6.6 |
| 9 | 8.7 | 8.7 | 9.4 | 6.0 | 5.5 | 7.0 | 1.2 | 1.2 | 1.1 | 5.3 | 5.2 | 5.8 |
| 10 | 7.6 | 7.7 | 8.0 | 5.6 | 4.8 | 6.9 | 1.3 | 1.4 | 1.3 | 4.4 | 4.3 | 4.7 |
| 11 | 7.0 | 7.2 | 7.6 | 5.0 | 4.6 | 6.2 | 1.1 | 1.2 | 1.0 | 4.5 | 4.7 | 4.5 |
| 12 | 7.9 | 8.1 | 8.3 | 5.7 | 5.2 | 6.9 | 1.3 | 1.4 | 1.3 | 4.8 | 4.6 | 5.4 |
| 13 | 8.4 | 7.9 | 9.3 | 5.3 | 4.3 | 6.7 | 1.3 | 1.3 | 1.2 | 4.4 | 3.4 | 5.7 |
| 14 | 7.6 | 7.6 | 8.1 | 5.4 | 4.4 | 7.2 | 1.3 | 1.2 | 1.4 | 4.9 | 4.5 | 5.6 |
| 15 | 7.1 | 7.3 | 7.1 | 4.9 | 4.3 | 6.2 | 1.1 | 1.3 | 0.9 | 3.5 | 3.3 | 3.9 |
| 16 | 7.8 | 7.2 | 9.1 | 5.9 | 5.2 | 7.2 | 1.4 | 1.4 | 1.4 | 5.1 | 4.8 | 5.6 |
| 17 | 8.4 | 8.4 | 8.4 | 6.0 | 5.6 | 6.6 | 1.3 | 1.5 | 0.9 | 4.9 | 5.1 | 4.4 |
| 18 | 7.7 | 7.5 | 8.7 | 6.2 | 5.5 | 7.5 | 1.5 | 1.8 | 1.2 | 5.2 | 5.2 | 5.4 |
| Mean | 7.7 | 7.6 | 8.4 | 5.5 | 4.8 | 6.7 | 1.3 | 1.4 | 1.2 | 4.8 | 4.6 | 5.4 |
| SD | 0.5 | 0.5 | 0.7 | 0.5 | 0.4 | 0.6 | 0.1 | 0.2 | 0.2 | 0.6 | 0.7 | 0.7 |
| CV | 7% | 7% | 8% | 8% | 9% | 9% | 10% | 13% | 13% | 12% | 15% | 13% |
The results are (mean ± SD): NAA=0.11±0.1, Cho=0.03±0.01, Cr=0.08±0.01, mI=0.08±0.08.