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. 2011 Aug 3;31(31):11396–11403. doi: 10.1523/JNEUROSCI.1393-11.2011

Figure 2.

Figure 2.

Self-administration, extinction, and reinstatement of cocaine seeking by intra-VTA injections of CRF in ShA (14 × 2 h/d) and LgA (14 × 6 h/d) rats and in saline self-administration control rats. A, Data represent the daily mean hourly numbers of self-administered infusions (±SE) in ShA, LgA, and Sal rats across the 14 day test period. Escalation was observed in LgA, but not ShA or Sal rats (**p < 0.05 overall effect), and self-administration was increased in LgA rats compared with ShA (and Sal) rats on days 5 and 9–14 of self-administration (*p < 0.05). The cumulative total cocaine intake (in milligrams per kilogram ± SE) in ShA and LgA rats is shown in the inset in A. Intake was markedly and significantly increased in LgA rats (**p < 0.001 vs ShA rats). B, Responding (±SE) during the final self-administration session (represented as the 2 h mean in LgA rats) and the 10 consecutive 2 h extinctions sessions is shown. Significant differences in extinction responding between ShA and LgA rats were not found. C, Significant intra-VTA CRF-induced reinstatement was observed in LgA but not ShA rats, and CRF-induced responding was significantly higher in LgA rats compared with ShA rats and Sal controls at both doses tested (*p < 0.05), and increased compared with vehicle at the 500 ng/side (but not the 250 ng/side) CRF dose (#p < 0.05). D, Effects on responding on the previously inactive lever during reinstatement testing were not found.