Table 1.

Ptch knockout mouse models for preclinical BCC treatment studies.

BCC model	Mode of BCC induction	Treatment	Reference
Pt ch neo12/+	UV	Cyclopamine	[60]
Pt ch neo12/+ skin punches	UV	CUR61414	[61]
Pt ch neo12/+	UV	α-difluoromethylornithine	[62]
Pt ch neo12/+	IR/UV	Tazarotene	[55]
Pt ch neo12/+	UV	Tazarotene, ATRA, AGN195813, AGN194204, AGN194310	[63]
Pt ch neo12/+	IR/UV	Celecoxib, sulindac, MF-tricyclic	[64]
Pt ch neo12/+	UV	Green/black tea	[54]
Pt ch neo12/+ K14-Cre-ER p53fl/fl	IR and conditional p53 ablation	CUR61414	[65]
Pt ch neo12/+ K14-Cre-ER p53fl/fl	IR and conditional p53 ablation	Itraconazole	[66]
Pt ch neo12/+ K14-Cre-ER p53fl/fl	IR and conditional p53 ablation	Vitamin D3	[67]
Pt ch flox/flox ER T2+/−	conditional Ptch ablation	Calcitriol	[68]

UV: ultraviolet radiation; IR: ionizing radiation.