Figure 1. Prevalence of Src staining in human pancreas tissue.

(A) There is a step-wise progression of Src expression from normal pancreas to chronic pancreatitis to advancing grade of pancreatic adenocarcinoma in both the cytoplasmic and membranous compartments. (B) The percentage of cases with negative staining (IHC staining index=0), weak staining (1+ to 2+), or strong staining (3+) in each diagnostic group are displayed. (C) Kaplan-Meier survival curves for overall survival of patients with adenocarcinoma according to cytoplasmic and membranous staining for Src are shown. The discontinuous line represents tumors that showed an immunoreactivity score < 2+ staining (n=24). Continuous line represents tumors with an immunoreactivity score > 2+ staining (n=36). Increased membranous Src staining results in decreased overall survival (p=0.001) while increased cytoplasmic Src staining results in improved overall survival (p=0.001).